Drug Name

Prandin (Repaglinide)

Drug Uses

Prandin is used for managing type 2 (non-insulin-dependent) diabetes. It is used in addition to diet and exercise to lower blood sugar in adults who cannot manage with diet, exercise, or diabetic medications alone. It may be used with other diabetes medicines.

How Taken

Use Prandin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Prandin by mouth at least 15 to 30 minutes before each meal. If you skip a meal, do not take the dose for the skipped meal. If you add an extra meal, take an extra dose with that meal.

Drug Class and Mechanism

Prandin is a meglitinide antidiabetic. It works to lower blood glucose (sugar) by stimulating the release of insulin from the pancreas gland. Prandin does not work in type 1 (insulin-dependent) diabetes, because in this condition the pancreas gland is not capable of making or releasing insulin.

Missed Dose

If you miss a dose of Prandin , skip the missed dose and go back to your regular dosing schedule.

Storage

Store at room temperature below 77 degrees F (25 degrees C) away from light and moisture.

Warnings/Precautions

Do NOT use Prandin if:

• you are allergic to any ingredient in Prandin
• you have type 1 diabetes (insulin-dependent diabetes) or have elevated ketone levels due to diabetes
• you are also taking gemfibrozil

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Prandin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription medicine, nonprescription medicine, herbal preparation or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of acidosis, kidney disease, or liver disease

Some MEDICINES MAY INTERACT with Prandin . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Rifampin because it may decrease Prandin 's effectiveness
• Beta blockers (eg, propranolol), gemfibrozil, imidazoles (eg, ketoconazole), macrolides and ketolides (eg, erythromycin, azithromycin), monoamine oxidase (MAO) inhibitors (eg, phenelzine), quinolones (eg, ciprofloxacin), or salicylates (eg, aspirin) because the risk of side effects, such as low blood sugar, may be increased
• Insulin because it may increase the risk of Prandin 's side effects

Possible Side Effects

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

• Changes in vision; diarrhea; headache; increased heartbeat; increased hunger; joint or back pain; nasal or chest congestion; nervousness; sinus inflammation; sweating; tiredness; tremor.

Seek medical attention right away if any of these SEVERE side effects occur:

• Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain.

More Information

If you have any questions about Prandin , please talk with your doctor, pharmacist, or other health care provider.
Prandin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.